When someone signs up for your topic X lead magnet, immediately tag them to profile them.
E.g.
Peter opts-in to get your blogging guide, tag him with "blogging".
John opts-into get your SEO guide, tag with "SEO".
This way you keep your email list neat and tidy.
And your emails become very relevant and on-point.
Want to email about blogging → send to those tagged with "blogging".
Want to email about SEO → send to those tagged with "SEO".
Do you segment your subscribers? If not, why?