Best Medicine season 2 premiere: date, time and channel (FOX, Sept 20)

Best Medicine returns for its second season on Sunday, September 20, 2026 at 8:00pm on FOX. The premiere, Be Careful What You Fish For, runs 60 minutes.

What the premiere covers

The season opener keeps the show's two threads running side by side. Martin is still struggling with his blood phobia — the central joke and the central problem of a series about a brilliant surgeon who cannot stand the sight of blood — while a mermaid washes ashore in Port Wenn to the amazement of the town. A subplot has Judith, a well-meaning local, causing havoc while on prescribed oxygen.

Where the series stands

Best Medicine premiered on January 4, 2026 and is listed as running, so this is a quick turnaround into a second season rather than a long gap. The premise has not changed: a surgeon leaves Boston for the small town where he spent childhood summers, and finds that his medical skill does not make up for his manner with the people who live there.

Air time, plainly

Show: Best Medicine, season 2, episode 1

Episode: Be Careful What You Fish For

Channel: FOX

Date: Sunday, September 20, 2026

Time: 8:00pm, network local slot

Running time: 60 minutes

A note on the time: FOX is a broadcast network, so primetime runs on the local clock rather than simultaneously across the country. 8:00pm means 8:00pm where you are, not a single national instant — which is why this page does not print a converted Pacific time.

Schedule and episode data from TVmaze, licensed CC BY-SA.

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