Does it make sense to start with your best idea when starting your 1st business?

I would start with the idea that motivates me most to get it done. IMHO.

'Best' is a strange word. Ideas can't be given a score out of 100. One idea isn't a 45, while another a 32. But you can look at ideas given your current access to markets and decide one is better left till later, maybe start a blog around one idea and see if you can gain traction in access to the market, while making another idea that addresses a market you already have a bit better access to.
Same goes for technical difficulty, build a base, gain your advantages, keep building.

Hey Lloret, some questions and some thoughts about this:

Do you really know your "best" idea is actually a great idea and will make you a millionaire or change the world? If no, do market validation first (build a landing page, buy some ads, speak with potential buyers). You can do all of that without actually "starting" the business but getting some insights and maybe pivot a bit (to make your idea even better). The rest depends a bit on the amount of time you have for your project(s) and how fast you can evaluate product-market-fit and problem-solution-fit for your actual idea. If that takes some time, try executing some different ideas in the meantime and gain some experience. But at the moment you feel confident enough and are sure your idea is a killer: Execute. And then never let it get you down if you really believe in your idea. 🚀

Good luck 🍀